Quantitative proteomics using formalin-fixed paraffin-embedded tissues of oral squamous cell carcinoma
نویسندگان
چکیده
منابع مشابه
Transcriptional profiling of oral squamous cell carcinoma using formalin-fixed paraffin-embedded samples.
Despite the advances in cancer treatment, the 5-year survival rate for oral cancer has not changed significantly for the past 40 years and still remains among the worst of all anatomic sites. Gene expression microarrays have been used successfully in the identification of genetic alterations in cancer development, however, these have hitherto been limited by the need for specimens with good qua...
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We recently developed a sensitive and flexible gene expression profiling system that is not dependent on an intact poly-A tail and showed that it could be used to analyze degraded RNA samples. We hypothesized that the DASL (cDNA-mediated annealing, selection, extension and ligation) assay might be suitable for the analysis of formalin-fixed, paraffin-embedded tissues, an important source of arc...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2009
ISSN: 1347-9032,1349-7006
DOI: 10.1111/j.1349-7006.2009.01227.x